Zosano
Drug Patch Delivery System
Zosano Pharma (previously a Johnson & Johnson Internal Venture) is a specialty pharmaceutical company developing a proprietary large molecule transdermal drug delivery system. Zosano’s Macroflux technology enables at-home, needle-free administration in the form of a drug-coated patch applied to the skin. They came to D2M with an accelerated clinical trial schedule, but with several outstanding user experience, performance and manufacturability issues. D2M’s integrated multidisciplinary services were the ideal partnership to keep Zosano on track towards successful commercialization.
The Details
In phased development, our engineers conceived and evaluated improvements to the product user interface while in parallel developing innovative measurement tools for more reliable device performance measurement. Armed with key device improvements from this exploration, D2M rapidly executed the device design for low volume manufacturability under Zosano’s design controls to meet performance and safety criteria for clinical trial. D2M also developed an integrated sensor measurement system for use as a lot clearance tool. The D2M team assisted with simultaneous validation of injection mold and measurement tools and device verification to converge by critical sample available dates.
Since this successful effort, D2M has become a research and development partner using our intimate product knowledge to conceive of advanced delivery concepts to enhance user experience, reduce cost and product size, and designing research tools to enhance Zosano’s understanding of their design controls.
D2M has become an invaluable partner in Zosano’s continued systems development.